Mr Newman said Zaman's poor English and health problems would make prison a particularly isolating place for him. Police were alerted and were taking the girl to the police station when she saw Zaman in the street and pointed him out to the officers as the man who molested her. Studies from our lab and others have shown that in utero SHS exposure exacerbates adult responses to environmental stressors, including house dust mites, Aspergillus fumigatus and SHS [ 18 , 21 , 22 ]. Results In utero SHS exposure significantly increased mean linear intercept and decreased the surface area per unit volume of the lungs in both males and females, indicating perturbation in alveolar developmental processes. We also showed that upon re-exposure to SHS as adult, mice exposed in utero to SHS exhibited altered lung structure [ 21 ].
This is due mostly to the fact the human lung is exposed to a multitude of irritants throughout life, e. The trial heard that Zaman pursued her in his car on December 14, , and told her he would rape her one day. Thus, unborn children are a vulnerable subpopulation involuntarily exposed to cigarette smoke and SHS. Studies from our lab and others have shown that in utero SHS exposure exacerbates adult responses to environmental stressors, including house dust mites, Aspergillus fumigatus and SHS [ 18 , 21 , 22 ]. Abstract Background An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke SHS during pregnancy with adverse outcomes in newborns. Recorder Khan made an indefinite Sexual Harm Prevention Order and Zaman was ordered to sign on the sex offender register without limit of time. To address this knowledge gap, in the present study we asked whether in utero SHS exposure alone, without any postnatal re-exposure to an irritant, is sufficient to alter lung structure and function in adult week old mice. He was the father of two very young children and he suffered from depression and diabetes. He was sacked by the private hire firm he worked for and the court heard he would not get another cab driver's licence with the conviction on his record. Received Feb 16; Accepted May Meanwhile, epidemiological studies associated in utero exposure to cigarette smoke with sustained lung deficiencies, which could lead to impaired lung function following additional postnatal exposures [ 8 , 24 — 26 ]. Thus, there is still insufficient evidence to define the long-term contribution of in utero SHS exposure alone, as a sole or baseline factor, to modification of lung function and structure, thereby predisposing to the development of lung diseases, such as asthma, emphysema, chronic bronchitis, fibrosis or cancer [ 29 — 31 ]. Published online Jun In this study, we asked whether the in utero SHS exposure alone is sufficient to alter lung structure and function in adult mice. He called her beautiful, grabbed her wrist and kissed her on the cheek. However, few studies have investigated the contribution of in utero SHS exposures to these same outcomes. As early as , the health consequences of SHS to children, particularly on the respiratory tract, were recognized and documented [ 16 ]. Police were alerted and were taking the girl to the police station when she saw Zaman in the street and pointed him out to the officers as the man who molested her. Overall, we have demonstrated that in utero exposure to SHS 1 elicits persistent well-documented pathophysiological and molecular changes in various adult lung disease models, upon re-exposure to an irritant as an adult, and 2 modulates responses related to lung function and structure, as well as transcriptomic alterations. Overall, our data suggest that in utero SHS exposure alone can predispose to adult lung diseases. She was frightened and tried to walk quickly away but Zaman got out of his vehicle and confronted her, prosecutor Jayne Beckett told jurors. Currently, over 5 million deaths worldwide occur annually due to direct tobacco use, with second-hand smoke SHS exposures being responsible for approximately , of those deaths [ 1 , 2 ]. More recent studies have shown that in utero exposure to environmental pollutants, including SHS, results in alterations of physical and physiological features of the fetus, as well as increased disease susceptibility in adulthood [ 17 — 20 ]. Qamar Zaman, 40, seized the child by the hips and demanded that she perform a sex act on him after following her in his car as she walked home from school, Bradford Crown Court heard. He grabbed her hips and pulled her towards his car, saying he wanted oral sex. This also suggests that in our model, lung structure changes may be necessary but are not sufficient to impair lung function.
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